Microsoft’s Technet site has a new Windows Vista Security Guide for IT Professionals.
Unfortunately, it really does seem to be aimed at Information Technology professionals, with information for users scattered hither and yon through the document:
Chapter 1: Implementing the Security Baseline
Chapter 2: Defend Against Malware
Chapter 3: Protect Sensitive Data
Chapter 4: Application Compatibility
Chapter 5: Specialized Security – Limited Functionality
http://www.microsoft.com/technet/windowsvista/security/guide.mspx